NIMH Clinical Trial Recruitment

For general information on clinical trials, browse the respective web pages for NIMH Clinical Trials and NIH Clinical Trials. Also see the NIMH Join a Mental Health Research Study web page and the NIH Learn about Clinical Studies web page.

October 1, 2018

NATIONWIDE RECRUITMENT: A STUDY OF BRAIN FUNCTION AND SYMPTOMS IN CHILDREN WITH SEVERE MOOD DYSREGULATION

This study seeks to learn more about the symptoms of severe mood dysregulation in children and adolescents ages 7-17. Children and adolescents with severe mood dysregulation (SMD) display chronic anger, sadness, or irritability, as well as hyperarousal (such as insomnia, distractibility, hyperactivity) and extreme responses to frustration (such as frequent, severe temper tantrums). Researchers will describe the moods and behaviors of children with these symptoms and use specialized testing and brain imaging to learn about the brain changes associated with this disorder.

Study participation begins with an initial outpatient evaluation that lasts one day. Then, testing and brain imaging are completed at two-three day outpatient visits which occur every two years until participants reach age 25. Phone contact occurs every six months in between visits.

Descriptive/Longitudinal Study: When children have severe mood dysregulation (SMD), do their brains work differently than those of other children? How do their symptoms change as the children grow up?
After a preliminary phone interview, participants may be invited to NIMH for an on-site assessment. Children must be in treatment with a psychiatrist or provider, and/or medically healthy and not currently hospitalized, psychotic, or suicidal.

A principal focus of the research is how mood, behavior, and brain development of children with SMD change over time. Study procedures at the two-three day visits may include questionnaires and interviews; paper-and-pencil and computer tests of mood, memory, and thinking; specialized computer games; and structural and functional Magnetic Resonance Imaging (MRI) scans. These visits occur every two years until age 25. Children continue in treatment with a provider or psychiatrist in their community. This study does not involve treatment medications.

To find out if you qualify, email NIMH or call 1-301-496-8381 [TTY: 1-866-411-1010].

  • Protocol Number: 02-M-0021
  • Principal Investigator: Ellen Leibenluft, M.D.

https://www.nimh.nih.gov/labs-at-nimh/join-a-study/trials/childrens-studies/brain-function-children-mood-irritability.shtml

 

September 1, 2018

NATIONWIDE RECRUITMENT: MAJOR DEPRESSION AND AV101

The primary purpose of this research study is to evaluate the safety and effectiveness of the oral drug AV-101 (an antagonist of the glycine receptor) versus placebo. The study aims to determine if this experimental drug has antidepressant effects and fewer side effects than other novel treatments for depression.

NIMH is enrolling moderately depressed individuals between the ages of 18 and 65 with hard-to-treat major depressive disorder. This inpatient study lasts up to 14 weeks and procedures include a medication taper, taking the research drug, taking placebo, and four brain imaging scans. Optional procedures include a lumbar puncture and a catheter placement in the spine two times. After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland and enrolls eligible participants from across the USA. Travel arrangements are provided, and costs are covered by NIMH (arrangements vary by distance). There is no cost to participate and compensation is provided.

First steps to participate include calling NIMH, learning specifics about the study, asking about your eligibility, and consenting to participate.

To find out if you qualify, email moodresearch@mail.nih.gov or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

  • Protocol Number: 15-M-0151
  • Principal Investigator: Carlos Zarate Jr, M.D.

https://www.nimh.nih.gov/labs-at-nimh/join-a-study/trials/adult-studies/major-depression-and-av101.shtml

 

June 1, 2018

NATIONWIDE RECRUITMENT

CONCERNED THAT YOUR TEENAGER HAS DEPRESSION?

Join a research study seeking to find causes and treatments of depression in teenagers.

The study is recruiting participants ages 11-17 who are depressed and have a pediatrician or medical provider. The study begins with an outpatient evaluation (clinical assessment, interviews, and questionnaires). Outpatient study visits include a clinical assessment, research tasks, and brain imaging, up to age 25. Eligible participants may receive treatment of evidence-based cognitive-behavioral therapy (CBT), and if indicated, standard medicines. Enrollment is from across the U.S. Transportation expenses to NIH in Bethesda, MD are reimbursed. There is no cost to participate; compensation is provided.
www.nimh.nih.gov/TeenDepressionStudy

Call 1-301-827-1350 [TTY: 1-866-411-1010] or Email depressedkids@mail.nih.gov

Department of Health & Human Services, National Institutes of Health, National Institute of Mental Health, Protocol Number: 18-M-0037

Social Media Messages:

  • YouTube Video: https://youtu.be/Ik3qMFWQ9Mg
  • Facebook:Concerned about your teen’s depression?Symptoms include depressed mood, loss of pleasure, lack of interest, problems with sleeping, eating, and concentration. Study seeks to find causes and treatments. Parental permission required. Contact us at depressedkids@mail.nih.gov or call 301-827-1350.
    www.nimh.nih.gov/TeenDepressionStudy
  • Twitter: Concerned about your teens depression? Research study enrolling ages 11-17 for evaluations and treatment. www.nimh.nih.gov/TeenDepressionStudy

 

May 1, 2018

NATIONWIDE RECRUITMENT: DESCRIPTIVE STUDY OF SEVERE IRRITABILITY

OUTPATIENT: ONE-DAY EVALUATION, AND MAY INCLUDE FOLLOW-UP VISITS UNTIL AGE 25

This NIMH study describes, over time, the moods and behavior of children and the associated brain changes. Participants must be in treatment with a physician, medically healthy, and not currently hospitalized, psychotic, or suicidal. Symptoms include chronic anger, sadness, or irritability, along with hyperarousal (such as insomnia, distractibility, hyperactivity), and extreme responses to frustration (such as frequent, severe temper tantrums). The study procedures include research and computer tasks, neuropsychological testing, and brain imaging and is recruiting youth ages 7-17. [02-M-0021]
https://www.nimh.nih.gov/labs-at-nimh/join-a-study/children/children-irritability.shtml

FDA LAUNCHES NEW PSA ON VETERANS AND CLINICAL TRIAL DIVERSITY

In recognition of National Minority Health Month, the FDA Office of Minority Health has joined forces with the Veterans Health Administration’s Office of Health Equity within the VA to release two new public service announcements on the importance of having diverse participants in clinical trials. Veterans can face unique health challenges, and diverse participants are needed in clinical trials to ensure that medical products, like medicines, vaccines, or devices, are safe and effective for everyone. http://www.fda.gov/MinorityHealth

 

April 1, 2018

JOIN THE CONVERSATION ABOUT ALZHEIMER’S RESEARCH PARTICIPATION

The National Institute on Aging (NIA) at NIH is seeking ideas from the wider community — advocates, clinicians, people with dementia, family members, caregivers, researchers, and site coordinators — about how to overcome barriers and optimize participation in Alzheimer’s research. Clinical trials and studies are critical to finding a treatment or cure for Alzheimer’s disease. Yet efforts in many cases to engage participants in Alzheimer’s research have not been able to keep pace with the need. NIA is seeking ideas on how to optimize recruitment by building trusting relationships in local communities, raising national awareness about participation in studies, enhancing the capacity of study sites, tracking progress, and cultivating a science of recruitment. https://nia-research.ideascale.com/

NIMH NATIONWIDE RECRUITMENT

CONCERNED THAT YOUR TEENAGER HAS DEPRESSION? NIH RESEARCH

JOIN A RESEARCH STUDY SEEKING TO FIND CAUSES AND TREATMENTS OF DEPRESSION IN TEENAGERS.

The study is recruiting participants ages 11-17 who are depressed and have a pediatrician or medical provider. The study begins with an outpatient evaluation (clinical assessment, interviews, and questionnaires). Outpatient study visits include a clinical assessment, research tasks, and brain imaging, up to age 25. Eligible participants may receive treatment of evidence-based cognitive-behavioral therapy (CBT), and if indicated, standard medicines. Enrollment is from across the U.S. Transportation expenses to NIH in Bethesda, MD are reimbursed. There is no cost to participate, compensation is provided.
www.nimh.nih.gov/TeenDepressionStudy

Call 1-301-827-1350 [TTY: 1-866-411-1010] or Email depressedkids@mail.nih.gov

Department of Health & Human Services, National Institutes of Health, National Institute of Mental Health, Protocol Number: 18-M-0037

FACEBOOK:

Concerned about your teen’s depression?

Symptoms include depressed mood, loss of pleasure, lack of interest, problems with sleeping, eating, and concentration. Study seeks to find causes and treatments. Parental permission required. Contact us depressedkids@mail.nih.gov or call 1-301-827-1350. www.nimh.nih.gov/TeenDepressionStudy

TWITTER:

Concerned about your teens depression? Research study enrolling ages 11-17 for evaluations and treatment www.nimh.nih.gov/TeenDepressionStudy

 

March 1, 2018

NATIONWIDE RECRUITMENT: DEPRESSION AND BRAIN FUNCTION

(Inpatient and/or Outpatient study: 8 weeks, and 3 once-a-month follow up visits or phone calls.) This depression research study tests the effects of the combination of TMS and psychotherapy on brain function. Participation includes research evaluations, brain scans, and active TMS and psychotherapy, or inactive TMS and psychotherapy. Recruiting ages 18-65 with major depressive disorder, who are free of other serious medical conditions. If you are currently taking anti-depressants, you may still be eligible. (17-M-0147). Call: 1-877-MIND-NIH, (1-877-646-3644), TTY: 1-877-411-1010, email moodresearch@mail.nih.gov, NIH, NIMH, Protocol #17-M-0147. https://www.nimh.nih.gov/labs-at-nimh/join-a-study/trials/adult-studies/depression-tms-psychotherapy-and-brain-function.shtml

FACEBOOK POST

This research study seeks depressed participants to test the effects of the combination of repetitive transcranial magnetic stimulation (TMS) and psychotherapy on brain function. Learn more and find out if you are eligible. 1-877-646-3644, TTY: 1-877-411-1010, email moodresearch@mail.nih.govNo cost to participate, compensation provided. Protocol #17-M-0147. https://www.nimh.nih.gov/labs-at-nimh/join-a-study/trials/adult-studies/depression-tms-psychotherapy-and-brain-function.shtml

TWITTER

Seeking adults 18-65 to participate in a depression and brain function research study.
https://www.nimh.nih.gov/labs-at-nimh/join-a-study/trials/adult-studies/depression-tms-psychotherapy-and-brain-function.shtml

UNDERREPRESENTATION OF MINORITIES IN RESEARCH STUDIES IS NOT DUE TO UNWILLINGNESS

African American and Latino adults are willing to participate in medical research, but they are not being asked, according to a study funded by National Institute on Minority Health and Health Disparities. The study results highlight the need for focused recruitment of racial and ethnic minorities in medical research studies. In particular, research recruitment efforts targeting minorities should highlight the value of medical research and provide increased understanding of human subjects protections.
https://obssr.od.nih.gov/research-spotlights-february-2018/#post1

 

February 1, 2018

NATIONWIDE RECRUITMENT—NIH RESEARCH: DEPRESSION IN TEENAGERS

Join a research study seeking to find causes and treatments of depression in teenagers. The study is recruiting participants ages 11-17 who are depressed and have a pediatrician or medical provider. The study begins with an outpatient evaluation (clinical assessment, interviews, and questionnaires). Outpatient study visits include a clinical assessment, research tasks, and brain imaging, up to age 25. Eligible participants may receive treatment of evidence-based cognitive-behavioral therapy and, if indicated, standard medicines. Enrollment is from across the U.S. Transportation expenses to NIH in Bethesda, MD are reimbursed. There is no cost to participate; compensation is provided.

Call 1-301-827-1350 [TTY: 1-866-411-1010] or Email depressedkids@mail.nih.gov
www.nimh.nih.gov/TeenDepressionStudy

Department of Health & Human Services, National Institutes of Health, National Institute of Mental Health, Protocol Number: 18-M-0037

 

January 15, 2018

CLINICAL RESEARCH MUST INCLUDE UNDERREPRESENTED GROUPS, NIH EXPERTS SAY; LACK OF REPRESENTATION JEOPARDIZES PERSONALIZED MEDICINE APPROACH

To realize the promise of personalized medicine, new research studies must include segments of the population often overlooked in clinical research: children, older adults, pregnant women, and individuals with physical, intellectual, and developmental disabilities. This assessment, made by the Director and Deputy Director of NICHD, is summarized in a Viewpoint article in the Journal of the American Medical Association. https://www.nichd.nih.gov/news/releases/122817-inclusion-clinical-research

JOIN A RESEARCH STUDY: ENROLLING NATIONALLY FROM AROUND THE COUNTRY

DEPRESSION EVALUATIONS FOR MEDICATION AND BRAIN IMAGING STUDIES

This study screens for various inpatient and outpatient studies that investigate the brain and experimental medications (such as ketamine and AV101) to quickly lift severe and hard-to-treat depressive symptoms.

Participation may include outpatient visits or inpatient stays lasting 4 to 12 weeks at the NIH Clinical Center, Bethesda, MD. Procedures may include: tapering off current psychiatric medications, a medication-free period, oral or intravenous medication versus placebo, and brain scans. You may also qualify for other studies that have different requirements and lengths of stay.

Participants must be ages 18-70 and free of serious medical conditions. These studies may enroll eligible participants from across the USA. Travel arrangements and compensation are provided. There is no cost to participate.

First steps to participate include, calling NIMH, learning study details, asking about your eligibility, and consenting to participate.

To find out if you qualify, email NIMH at moodresearch@mail.nih.gov or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

https://www.nimh.nih.gov/labs-at-nimh/join-a-study/trials/adult-studies/depression-evaluations-for-medication-and-brain-imaging-studies.shtml

 

December 1, 2017

NATIONWIDE RECRUITMENT: NIH RESEARCH STUDY: DEPRESSION IN TEENAGERS

NIMH study seeks to understand the causes of depression in teenagers. As part of a larger study looking at mood dysregulation, this part of the study is currently recruiting medically healthy teenagers ages 12 to 17, who meet the criteria for major depressive disorder and are in treatment with a physician. Study participation begins with an initial one-day evaluation. Research visits may include annual outpatient visits up to age 25, and/or a four- to 15-week inpatient treatment. Call 1-301-496-8381 [TTY: 1-866-411-1010],
Email depressedkids@mail.nih.gov

Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health
http://go.usa.gov/x8Xmk

Resource Listing or Facebook:

NIH Research Study: Understanding the causes of depression in teenagers. Currently recruiting ages 12-17. Initial 1-day evaluation for outpatient visits annually and/or 4- to 15-week inpatient treatment.

Call 1-301-496-8381 [TTY: 1-866-411-1010] or Email depressedkids@mail.nih.gov
http://go.usa.gov/x8Xmk

Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health

Twitter:

Teenagers with Depression: NIH Research study currently recruiting ages 12-17 for outpatient visits & treatment to understand the causes of depression.
http://go.usa.gov/x8Xmk

 

November 1, 2017

DEPRESSION, REPEATED DOSES OF KETAMINE, AND NEUROIMAGING

The purpose of this study is to evaluate the rapid and sustained antidepressant effects of repeat doses of ketamine in the brain. NIMH scientists want to learn how ketamine affects areas of the brain important in regulating mood and if there are unique signatures that could help predict who may respond to the drug. They also want to see if repeated doses of ketamine are safe and effective in treating the symptoms of depression.

NIMH is enrolling eligible adults, ages 18 to 65 with major depressive disorder. This in-patient study lasts 14-20 weeks and procedures include a medication taper and drug-free period, taking repeated doses of the research drug, taking placebo, multiple brain imaging scans, transcranial magnetic stimulation, and psychological testing. After completing the study, participants can receive short-term care at the NIH while transitioning back to a provider.

The study is conducted at the NIH Clinical Center in Bethesda, MD. There is no cost to participate and compensation is provided. This study enrolls eligible participants from across the US. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

The first steps to participate include calling NIMH, learning study details, asking about your eligibility, and consenting to participate.

To find out if you qualify, email NIMH at moodresearch@mail.nih.gov,or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Protocol Number: 17-M-0060

Principal Investigator: Carlos Zarate, Jr., M.D.
https://www.nimh.nih.gov/labs-at-nimh/join-a-study/trials/adult-studies/depression-repeated-doses-of-ketamine-and-neuroimaging.shtml