NIMH Clinical Trial Recruitment

For general information on clinical trials, browse the respective web pages for NIMH Clinical Trials and NIH Clinical Trials. Also see the NIMH Join a Mental Health Research Study web page and the NIH Learn about Clinical Studies web page.

NATIONWIDE RECRUITMENT

DEPRESSION, TMS, PSYCHOTHERAPY AND BRAIN FUNCTION

This research study seeks depressed participants to test the effects of the combination of repetitive transcranial magnetic stimulation (TMS) and psychotherapy on brain function.

This study is enrolling eligible adults ages 18-65 with major depressive disorder, who are free of other serious medical conditions. If you are currently taking anti-depressants, you may still be eligible.

This inpatient and/or outpatient study involves daily visits for 8 weeks followed by once-monthly visits for 3 months. Participation includes research evaluations, brain scans, and active TMS and psychotherapy, or inactive TMS and psychotherapy. Those who received inactive TMS may receive active TMS after the experimental phase is completed. After completing the study, participants receive short-term care at the NIH while transitioning back to a provider. The 3 monthly follow up visits can be conducted via telephone.

All clinical evaluations, research tasks and visits are free of cost. Participants are compensated for research procedures. The study is conducted at the NIH in Bethesda, Maryland, and is enrolling participants nationwide, from across the United States. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance).

To find out if you qualify, email NIMH or call 1-301-827-0176 [TTY: 1-866-411-1010].

INVESTIGATING THE GENETICS OF BIPOLAR DISORDER IN THOSE AFFECTED AND THEIR FAMILY MEMBERS

Researchers are looking for genes that may affect a person’s chances of developing bipolar disorder. You can participate in this research study if you are over 18, have a bipolar diagnosis, or have a family member with bipolar disorder.

This study includes a telephone interview (2-4 hours) and a blood sample (blood work from your physician.) The purpose of this study is to identify genes that may contribute to the development of bipolar disorder (manic depression), and related conditions. Bipolar disorder is a common and potentially life-threatening mood disorder. The tendency to develop bipolar disorder can be inherited, but this is poorly understood and probably involves multiple genes.

This study will use genetic markers to map and identify genes that contribute to bipolar disorder. Families and individuals who have the disorder are asked to contribute personal information and a blood sample to an anonymous national database. This information will aid scientists around the world who are working together to develop better treatments for this serious mood disorder.

To find out if you qualify, email NIMH or call 1-866-644-4363 [TTY: 1-866-411-1010].

A STUDY OF SCHIZOPHRENIA AND THE BRAIN: A SIX-MONTH INPATIENT EVALUATION STUDY

The National Institute of Mental Health in Bethesda, Maryland, invites qualifying adults who have been diagnosed with schizophrenia or schizoaffective disorder to participate in an inpatient research study at the NIH Clinical Center. In this study, researchers will be evaluating how the brain works in individuals diagnosed with schizophrenia to better understand the underlying causes of this illness. This study is usually six months long and generally has three phases. The first phase involves a thorough evaluation of the diagnosis, medications, and treatment. The second phase includes evaluations during periods on and off standard medications, with each period ranging from four to six weeks. The third phase focuses on stabilization, treatment, and discharge planning. Evaluations include a variety of medical, cognitive, neurological, and neurocognitive assessments. Advanced neuroimaging techniques (e.g., MRI, MEG, and PET) are used along with specialized cognitive tests designed to understand specific functions of the brain. Individuals interested in the study can find out if they qualify by emailing NIMH at schizophrenia@mail.nih.gov or calling 301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010]. Protocol #89-M-0160.
https://www.nimh.nih.gov/research/research-conducted-at-nimh/join-a-study/trials/adult-studies/a-study-of-schizophrenia-and-the-brain-a-six-month-inpatient-evaluation-study.shtml

DEPRESSION AND BRAIN FUNCTION

This inpatient and/or outpatient depression research study tests the effects of the combination of transcranial magnetic stimulation (TMS) and psychotherapy on brain function. Participation lasts eight weeks, followed by three once-a-month follow up visits or phone calls and includes research evaluations, brain scans, and active TMS and psychotherapy, or inactive TMS and psychotherapy. The study team is recruiting adults ages 18-65 with major depressive disorder, who are free of other serious medical conditions. Individuals who are currently taking antidepressants may still be eligible. For more information, call 1-877-MIND-NIH, (1-877-646-3644), TTY: 1-877-411-1010, or send an email to moodresearch@mail.nih.gov, National Institutes of Health, National Institute of Mental Health, Protocol #17-M-0147.
https://www.nimh.nih.gov/research/research-conducted-at-nimh/join-a-study/trials/adult-studies/depression-tms-psychotherapy-and-brain-function.shtml

FINDING CAUSES AND TREATING DEPRESSION IN TEENAGERS

The study is recruiting participants ages 11-17 who are depressed and have a pediatrician or medical provider. The study begins with an outpatient evaluation (clinical assessment, interviews, and questionnaires). Outpatient study visits include a clinical assessment, research 13 tasks, and brain imaging, up to age 25. Eligible participants may receive treatment of evidencebased cognitive behavioral therapy and, if indicated, standard medicines. Enrollment is from across the U.S. Transportation expenses to NIH in Bethesda, MD are reimbursed. There is no cost to participate and compensation is provided. For more information, call 1-301-827-1350 [TTY: 1-866-411-1010] or email depressedkids@mail.nih.gov. Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Protocol Number: 18-M-0037. www.nimh.nih.gov/TeenDepressionStudy

DEPRESSION, REPEATED DOSES OF KETAMINE, AND NEUROIMAGING

NIMH is conducting a study to evaluate the rapid and sustained antidepressant effects of repeat doses of ketamine. This 14- to 20-week inpatient study is enrolling eligible depressed adults, ages 18 to 65 from across the U.S., who are free of other serious medical conditions. NIMH will pay for travel to the NIH Clinical Center in Bethesda, MD. There is no cost to participate and compensation is provided. For more information, call 1-877-MIND-NIH (1-877-646-3644) [TTY: 1-866-411-1010] or email moodresearch@mail.nih.gov. Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Protocol #, 17- M-0060. https://www.nimh.nih.gov/research/research-conducted-at-nimh/join-astudy/ trials/adult-studies/depression-repeated-doses-of-ketamine-and-neuroimaging.shtml